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Inhibition of autophagy in hematopoietic stem cell impairs megakaryopoiesis and platelet function. Inhibition of autophagy by genetic deletion of Atg7 in mice at different stages of lineage development impairs megakaryocyte differentiation, as well as platelet function. MK-PPF, Proplatelet-forming megakaryocyte. Atg7 KO, Atg7 knockout.
