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M2698 inhibited p70S6K activity, induced feedback loop phosphorylation on Akt and suppressed Akt activity in breast cancer cell lines. HCC1419 and MDA-MB-453 cells were treated with 0.3 µM or 1 µM M2698 for 24 h. PI3K pathway modulation and feedback loop induction were monitored by western blot analysis of cell lysates. DMSO, dimethysulfoxide; WCE, whole cell extract.
