Figure 5.

M2698 inhibited growth of human breast cancer xenografted tumors. A. Mice bearing MDA-MB-468 human TNBC xenograft tumors (n=8) were treated with vehicle or M2698 10, 20 and 30 mg/kg qd po. B. Mice bearing MDA-MB-453 Her2-expressing human breast xenograft tumors (n=10) were treated with vehicle or M2698 10 or 20 mg/kg qd po. C. Mice bearing JIMT-1 Her2+ human breast xenograft tumors (n=10) were treated with vehicle or M2698 10 or 20 mg/kg qd po. ^a,b,cTreatment means with the same superscript are not significantly different (P>0.05). po, oral administration; qd, once daily; SEM, standard error of the mean. IC₅₀, concentration causing 50% inhibition; mut, mutation.