Figure 3.

CE-TOFMS analysis of intracellular metabolites related to nucleotide and to Gly/Ser/Cys metabolic pathway after 24 h of exposure to acidosis: Bar graphs show the relative intracellular amount of metabolites. The bars correspond to the mean values of the three OS cell lines under neutral and acidic conditions (blue and red, respectively), and to the mean of the two normal Fb cultures under neutral and acidic conditions (green and orange, respectively), mean ± SD. Metabolic pathway maps were first written by VANTED software at HMT, and the copyright has been provided to the authors. A. Purine and pyrimidine metabolic pathways; B. Gly/Ser/Cys and porphyrin metabolic pathways.