Table 3.
Metabolites significantly altered in acidic vs. neutral conditions in OS cells, by CE-TOFMS analysis
| Compound name | Category | Acidic pH | Neutral pH | Acidic/Neutral | P-value | ||
|---|---|---|---|---|---|---|---|
|
| |||||||
| Mean [pmol/109 cells] | SD | Mean [pmol/109 cells] | SD | ||||
| Fumaric acid | TCA cycle | 4.67 | 3.30 | 23.79 | 3.90 | 0.20 | 0.028* |
| Malic acid | TCA cycle, Pyruvate metabolism | 50.44 | 27.82 | 250.28 | 52.38 | 0.20 | 0.017* |
| Nicotinamide | Cholesterol reducer, Vitamine B | 10.86 | 2.53 | 3.70 | 0.95 | 2.94 | 0.044* |
| Glycerophospho choline | Glycerol-lipid metabolism, osmolytes | 2532.93 | 637.55 | 397.00 | 134.11 | 6.38 | 0.037* |
Welch’s t-test was used to evaluate the ratios of Acidic vs. Neutral conditions in osteosarcoma (OS) cells.
*
p < 0.05.