Table 2.
The biology function and involved disease of CaMKII analyzed by ingenuity pathway analysis
| Category | Function Annotation | p-value | Molecules |
|---|---|---|---|
| Cell Death and Survival | Cell death | 4.50E-07 | ABCD1, AKAP8, ANXA2, AP2B1, BAG3, BAX, C1QBP, CAMK2, CAPNS1, CASP14, CAT, CBFB, CDA, CDC37, CHTOP, COX5A, CSNK1A1, CSNK2A2, CSTA, CSTB, DDX17, DNMT1, DYNC1H1, EHD4, EIF3B, EIF3G, EIF3I, EIF4E, EIF5A, ELAVL1, EPHA2, FIS1, FKBP8, GJB2, GLRX, GPX1, HIST1H1C, HMGA1, HNRNPA1, HNRNPK, HPRT1, HSP90AA1, HYPK, IGF2R, ILF2, IMPDH2, ISG15, ITPR3, KPNA2, M6PR, MANF, MCTS1, MIF, MLKL, MRPL41, MRPS30, MSN, MT2A, NCKAP1, NDUFAB1, NME1, NUP62, OLFM1, PAK2, PAM16, PARK7, PCMT1, PCNA, PELP1, PNPT1, PPIB, PPP1CC, PRDX1, PRDX6, PRKAR1A, PSMB1, PSME3, PTRH2, PURA, PXN, RBM3, RBX1, RHOG, RPL10, RPS19, RRM2, S100A10, S100A11, S100P, SEC61G, SF3B6, SLC25A5, SLC3A2, SMARCC1, SPR, SRSF1, STMN1, SUPV3L1, TARDBP, TIMM50, TMED10, TMSB10/TMSB4X, TOP1, TPD52, TPM3, TUFM, UBE2M, VAPA, VASP, XRCC5, YARS |
| Cell death of tumor cell lines | 2.16E-06 | ANXA2, BAG3, BAX, CAMK2, CAPNS1, CASP14, CAT, CDA, CHTOP, COX5A, CSNK1A1, CSNK2A2, CSTA, DYNC1H1, EIF3G, EIF4E, ELAVL1, EPHA2, FKBP8, GLRX, GPX1, HMGA1, HNRNPA1, HNRNPK, HYPK, IGF2R, ILF2, ITPR3, KPNA2, MIF, MLKL, MSN, MT2A, NME1, PAK2, PARK7, PCNA, PELP1, PRDX1, PRKAR1A, PTRH2, RBX1, RPS19, RRM2, S100A11, SEC61G, SLC25A5, SLC3A2, SMARCC1, SRSF1, STMN1, TARDBP, TMED10, TMSB10/TMSB4X, TOP1, TPD52, TUFM, XRCC5, YARS | |
| Necrosis | 4.54E-07 | ANXA2, AP2B1, BAG3, BAX, CAMK2, CAPNS1, CASP14, CAT, CBFB, CDA, CDC37, CHTOP, COX5A, CSNK1A1, CSNK2A2, CSTA, DDX17, DNMT1, DYNC1H1, EHD4, EIF3B, EIF3G, EIF3I, EIF4E, ELAVL1, EPHA2, FKBP8, GJB2, GLRX, GPX1, HIST1H1C, HMGA1, HNRNPA1, HNRNPK, HPRT1, HSP90AA1, HYPK, IGF2R, ILF2, ISG15, ITPR3, KPNA2, M6PR, MANF, MCTS1, MIF, MLKL, MSN, MT2A, NDUFAB1, NME1, PAK2, PARK7, PCNA, PELP1, PNPT1, PPP1CC, PRDX1, PRDX6, PRKAR1A, PSMB1, PSME3, PTRH2, PURA, PXN, RBM3, RBX1, RHOG, RPL10, RPS19, RRM2, S100A10, S100A11, S100P, SEC61G, SF3B6, SLC25A5, SLC3A2, SMARCC1, SRSF1, STMN1, TARDBP, TMED10, TMSB10/TMSB4X, TOP1, TPD52, TUFM, UBE2M, VAPA, XRCC5, YARS | |
| Apoptosis of tumor cell lines | 1.35E-06 | ANXA2, BAG3, BAX, CAMK2, CAPNS1, CASP14, CAT, COX5A, CSNK1A1, CSNK2A2, CSTA, DYNC1H1, EIF4E, ELAVL1, EPHA2, FKBP8, GLRX, GPX1, HMGA1, HNRNPA1, HNRNPK, HYPK, IGF2R, ITPR3, KPNA2, MIF, MSN, MT2A, NME1, PAK2, PARK7, PCNA, PELP1, PRDX1, PRKAR1A, PTRH2, RBX1, RPS19, RRM2, S100A11, SEC61G, SLC25A5, SMARCC1, SRSF1, STMN1, TMED10, TMSB10/TMSB4X, TOP1, TPD52, XRCC5 | |
| Apoptosis | 1.19E-05 | AKAP8, ANXA2, BAG3, BAX, C1QBP, CAMK2, CAPNS1, CASP14, CAT, CBFB, CDC37, COX5A, CSNK1A1, CSNK2A2, CSTA, CSTB, DDX17, DNMT1, DYNC1H1, EHD4, EIF3B, EIF3I, EIF4E, EIF5A, ELAVL1, EPHA2, FIS1, FKBP8, GLRX, GPX1, HIST1H1C, HMGA1, HNRNPA1, HNRNPK, HSP90AA1, HYPK, IGF2R, ISG15, ITPR3, KPNA2, MCTS1, MIF, MRPL41, MRPS30, MSN, MT2A, NCKAP1, NME1, NUP62, PAK2, PAM16, PARK7, PCMT1, PCNA, PELP1, PNPT1, PPP1CC, PRDX1, PRDX6, PRKAR1A, PSMB1, PTRH2, PXN, RBM3, RBX1, RHOG, RPL10, RPS19, RRM2, S100A10, S100A11, SEC61G, SF3B6, SLC25A5, SMARCC1, SRSF1, STMN1, SUPV3L1, TARDBP, TMED10, TMSB10/TMSB4X, TOP1, TPD52, UBE2M, VASP, XRCC5, YARS | |
| Cell viability | 5.92E-03 | AP2B1, BAG3, BAX, CAMK2, CAT, CBFB, DNMT1, EHD4, EIF4A3, EIF4E, ELAVL1, GPX1, HMGA1, HNRNPUL2, IGF2BP3, IGF2R, MIF, NME1, NOP58, PAK2, PARK7, PCNA, PPP1CC, PRDX6, PRKACB, PRKAR1A, PRPF8, PSMA1, PSME3, RPL27, RPL38, RRM2, S100P, SMC3, SNRPA1, SNRPD1, STMN1, TARDBP, TOP1, XRCC5 | |
| Cell survival | 3.32E-03 | AP2B1, BAG3, BANF1, BAX, CAMK2, CAT, CBFB, DNMT1, EHD4, EIF4A3, EIF4E, ELAVL1, EPHA2, GLRX, GPX1, HMGA1, HNRNPUL2, IGF2BP3, IGF2R, MIF, NME1, NOP58, PAK2, PARK7, PCNA, PPIB, PPP1CC, PRDX6, PRKACB, PRKAR1A, PRPF8, PSMA1, PSME3, RPL27, RPL38, RRM2, S100P, SMC3, SNRPA1, SNRPD1, STMN1, TARDBP, TOP1, XRCC5 | |
| DNA Replication, Recombination, and Repair | Metabolism of DNA | 3.27E-04 | BAX, CAMK2, GPX1, HMGA1, HNRNPA1, KPNA2, NME1, PAM16, PCNA, POLE3, PPIB, PPP1CC, PRDX6, PURA, PXN, S100A11, SMC3, TOP1, XRCC5 |
| Cell Cycle | Cell cycle progression | 1.20E-02 | AKAP8, BAX, BCCIP, C1QBP, CAMK2, CDC37, CSNK1A1, CSNK2A2, DDX17, DNMT1, DYNC1H1, EIF4E, GPX1, HYPK, MARCKS, MIF, NME1, PAK2, PCNA, PELP1, PRDX1, PRKAR1A, PURA, RBM3, RBX1, RCC1, RPS15A, SMC3, STMN1, TOP1, TRIM25, TXLNG |