Table 4.

Raw values (+/− standard deviation) for proteins measured at each time point

Analyte	A0	D0	p-value Air vs. Diesel	A1	p-value fold Change vs. day 0	D1	p-value fold Change vs. day 0	p-value day 1 Δ Air vs. Δ Diesel	A2	p-value Fold Change vs. day	D2	p-value Fold Change vs. day	p-value day 1 Δ Air vs. Δ Diesel	A7-10	p-value Fold Change vs. day	D7-10	p-value Fold Change vs. day	p-value day 1 Δ Air vs. Δ Diesel
ECP (pg/mL)	160.80 ± 168.02	88.60 ± 136.33	0.26	92.78 ± 111.3	0.28	112.1 ± 97.54	0.10	0.04	134.0 ± 177.0	0.55	98.77 ± 88.44	0.02	0.02	158.7 ± 226.9	0.56	87.99 ± 93.66	0.24	0.20
Eotaxin-1 (pg/mL)	457.94 ± 456.0	386.76 ± 190.12	0.73	498.47 ± 413.36	0.16	541.76 ± 180.13	0.01	0.64	541.29 ± 302.67	0.01	573.27 ± 164.43	0.01	0.20	611.63 ± 378.14	0.09	734.22 ± 418.35	0.06	0.78
IP-10 (pg/mL)	12923.64 ± 26721.96	9991.60 ± 18496.68	0.98	21627 ± 50661	0.11	6829 ± 13175	0.02	0.007	62228 ± 168311	0.003	18059 ± 32152	0.16	0.08	37629 ± 100776	0.08	27868 ± 64717	0.05	0.81
CXCR3 (MFI)	10050.0 ± 368.76	13521.22 ± 6214.61	0.40	8693.36 ± 4076.98	0.69	8551.67 ± 630921	0.44	0.15	8921.27 ± 2520.99	0.81	8604.67 ± 3702.20	0.16	0.21	9858.60 ± 2904.61	0.47	9534.75 ± 5619.12	0.13	0.53
Granzyme B (pg/mL)	59.99 ± 105.89	21.58 ± 15.63	0.21	38.26 ± 33.15	0.82	34.08 ± 30.00	0.05	0.098	50.37 ± 55.84	0.13	29.75 ± 32.93	0.17	0.92	38.19 ± 46.88	0.92	166.47 ± 393.99	0.009	0.098
Perforin (pg/mL)	161.29 ± 413.53	51.61 ± 33.61	0.39	126.65 ± 276.71	0.70	83.97 ± 97.26	0.12	0.22	123.32 ± 257.77	0.56	55.80 ± 36.13	0.21	0.47	211.79 ± 391.73	0.85	218.74 ± 429.65	0.10	0.22

MFI mean fluorescence intensity. P values based on fold change over each individual’s baseline (D0) value. P value between treatment groups compares protein expression relative to baseline, air exposure vs. diesel exposure. P-values generated via un-paired, non-parametric Mann-Whitney t-test

significant differences are in bold