Table 2.
Methylation profiles in sperm from men with normal weight at the DMRs of imprinted genes
Methylation % in sperm from men with normal BMI | ||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
MEG3-IG | MEG3 | PEG1/MEST | IGF2 | H19 | GRB10 | NNAT | NDN | SNRPN | SGCE/PEG10 | PEG3 | PLAGL1 | |||||||||||||
% | SE | % | SE | % | SE | % | SE | % | SE | % | SE | % | SE | % | SE | % | SE | % | SE | % | SE | % | SE | |
CpG 1 | 0.84 | 0.38 | 0.65 | 0.11 | 91.80 | 0.25 | 95.28 | 0.40 | 0.87 | 0.19 | 0.61 | 0.19 | 1.90 | 0.32 | 2.53 | 0.18 | 3.48 | 0.57 | 1.50 | 0.22 | 4.03 | 0.89 | ||
CpG 2 | 79.02 | 0.48 | 2.68 | 0.53 | 1.20 | 0.08 | 92.90 | 0.36 | 66.71 | 0.93 | 2.81 | 0.17 | 1.90 | 0.25 | 1.26 | 0.34 | 1.59 | 0.16 | 1.91 | 0.58 | 1.62 | 0.25 | 3.90 | 0.91 |
CpG 3 | 73.99 | 0.36 | 1.83 | 0.56 | 2.06 | 0.14 | 96.99 | 0.37 | 92.79 | 0.34 | 1.32 | 0.17 | 2.99 | 0.28 | 1.27 | 0.21 | 1.86 | 0.19 | 3.69 | 0.61 | 1.58 | 0.24 | 4.57 | 0.82 |
CpG 4 | 85.85 | 0.46 | 3.10 | 0.51 | 2.35 | 0.19 | 95.29 | 0.31 | 1.22 | 0.18 | 1.54 | 0.31 | 0.74 | 0.15 | 4.25 | 0.56 | 1.19 | 0.21 | 4.20 | 0.91 | ||||
CpG 5 | 80.01 | 0.37 | 1.71 | 0.56 | 2.75 | 0.16 | 1.58 | 0.30 | 2.63 | 0.59 | 1.70 | 0.27 | 3.99 | 0.86 | ||||||||||
CpG 6 | 1.89 | 0.56 | 2.14 | 0.16 | 2.10 | 0.25 | 4.44 | 0.63 | 1.05 | 0.25 | 3.32 | 0.77 | ||||||||||||
CpG 7 | 2.52 | 0.53 | 1.91 | 0.24 | ||||||||||||||||||||
CpG 8 | 2.21 | 0.52 | 0.92 | 0.22 | ||||||||||||||||||||
CpG 9 | 2.23 | 0.24 | ||||||||||||||||||||||
CpG 10 | 1.97 | 0.21 | ||||||||||||||||||||||
Mean | 79.72 | 0.33 | 2.10 | 0.51 | 1.56 | 0.08 | 93.90 | 0.28 | 87.51 | 0.34 | 1.85 | 0.16 | 1.83 | 0.26 | 1.61 | 0.28 | 1.65 | 0.16 | 3.40 | 0.58 | 1.57 | 0.23 | 4.00 | 0.84 |
Results shown here describe methylation profiles for normal weight men (BMI < 25). The DNA methylation percentages are presented for each DMR, by the individual CpG site studied. The calculated mean for each DMR is shown on the bottom line