Table 5.

Multivariate Cox Proportional Hazard Analysis of Clinical, Biopsy and Imaging Variables for the Prediction of Treatment Failure after Radical Prostatectomy. Bold type indicates statistical significance.

Model	Variable	Category	HR	[95% CI]	p value
1 (Clinical)	# Positive Biopsy Cores (NPC)		1.22	[1.09–1.37]	0.0004
	NCCN Clinical Risk Score (CRS)				<0.0001
		Low	REF
		Intermediate	2.02	[0.79–5.17]
		High	11.1	[4.46–27.63]
2 (Clinical + MRI Stage)	# Positive Biopsy Cores (NPC)		1.19	[1.06–1.33]	0.0024
	NCCN Clinical Risk Score (CRS)				<0.0001
		Low	REF
		Intermediate	2.0	[0.78–5.12]
		High	8.75	[3.39–22.57]
	MRI Stage				0.0378
		1–3	REF
		4–7	2.31	[1.05–5.07]
3 (Clinical + MRI stage + # index lesion voxels)	# Positive Biopsy Cores (NPC)		1.15	[1.02–1.3]	0.023
	NCCN Clinical Risk Score (CRS)				<0.0001
		Low	REF
		Intermediate	1.74	[0.66–4.57]
		High	7.41	[2.83–19.43]
	MRI Stage				0.16
		1–3	REF
		4–7	1.78
	# MRSI Voxels (NILV)		1.04	[1.01–1.08]	0.0159
4 (Clinical + MRI stage + # high grade voxels)	# Positive Biopsy Cores (NPC)		1.16	[1.03–1.31]	0.0151
	NCCN Clinical Risk Score (CRS)				<0.0001
		Low	REF
		Intermediate	1.8	[0.69–4.7]
		High	7.86	[3.02–20.44]
	MRI Stage				0.0458
		1–3	REF	[1.02–4.94]
		4–7	2.24
	# High grade MRSI voxels		1.11	[1.04–1.18]	0.0016
	(NHGV)
5 (Clinical + MRI stage + # zero polyamine voxels)	# Positive Biopsy Cores (NPC)		1.17	[1.04–1.32]	0.0097
	NCCN Clinical Risk Score (CRS)				<0.0001
		Low	REF
		Intermediate	1.78	[0.68–4.65]
		High	7.8	[2.98–20.43]
	MRI Stage				0.21
		1–3	REF
		4–7	1.71	[0.74–3.96]
	# undetectable polyamine voxels (NUPV)		1.07	[1.02–1.13]	0.0056