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. Author manuscript; available in PMC: 2016 Nov 5.
Published in final edited form as: Nature. 2016 Apr 20;533(7601):115–119. doi: 10.1038/nature17950

Figure 4. Mice with LAP deficiencies display symptoms of an autoinflammatory disorder.

Figure 4

(A–E). Indicated serum cytokines in co-housed 52 wk old animals. In all cases, Cre indicates LysM-Cre. Error bars represent standard deviation (*p < 0.001). Numbers of animals are provided in Supplemental Methods. Color scheme represents LAP-deficient, autophagy-deficient genotypes (green), autophagy-deficient, LAP-sufficient (red), and autophagy-sufficient, LAP-deficient (blue). Values for one cohort of TIM4+/+ and TIM4−/− animals are shown for comparison in all cases (black) in A–E.