Table 3.
Odds ratios for endometrial cancer associated with tertiles of androgen and SHBG concentrations, with and without adjustment for BMI
| Hormone | Number of cases/controls | Unadjusted modela | Model adjusted for BMIb | ||
|---|---|---|---|---|---|
| OR (95 % CI) | p-trend | OR (95 % CI) | p-trend | ||
| Total testosterone | |||||
| Tertile 1 | 45/103 | 1.0 (ref) | 1.0 (ref) | ||
| Tertile 2 | 52/94 | 1.31 (0.79, 2.15) | 1.30 (0.78, 2.19) | ||
| Tertile 3 | 58/87 | 1.59 (0.96, 2.64) | 0.08 | 1.37 (0.81, 2.32) | 0.26 |
| Free testosterone | |||||
| Tertile 1 | 37/79 | 1.0 (ref) | 1.0 (ref) | ||
| Tertile 2 | 41/81 | 1.08 (0.64, 1.94) | 0.98 (0.57, 1.70) | ||
| Tertile 3 | 52/68 | 1.76 (1.01, 3.07) | 0.047 | 1.33 (0.73, 2.42) | 0.36 |
| DHEAS | |||||
| Tertile 1 | 53/98 | 1.0 (ref) | 1.0 (ref) | ||
| Tertile 2 | 50/104 | 0.85 (0.53, 1.36) | 0.80 (0.50, 1.30) | ||
| Tertile 3 | 57//98 | 1.11 (0.69, 1.78) | 0.70 | 0.89 (0.54, 1.46) | 0.60 |
| Androstendione | |||||
| Tertile 1 | 49/102 | 1.0 (ref) | 1.0 (ref) | ||
| Tertile 2 | 59/95 | 1.30 (0.81, 2.09) | 1.26 (0.78, 2.03) | ||
| Tertile 3 | 51/101 | 1.07 (0.65, 1.78) | 0.80 | 0.94 (0.56, 1.59) | 0.82 |
| SHBG | |||||
| Tertile 1 | 59/68 | 1.0 (ref) | 1.0 (ref) | ||
| Tertile 2 | 29/99 | 0.37 (0.22, 0.63) | 0.43 (0.25, 0.76) | ||
| Tertile 3 | 48/80 | 0.71 (0.43, 1.18) | 0.16 | 0.99 (0.57, 1.73) | 0.92 |
aConditional logistic regression (matching factors: cohort, age, and date of blood donation)
bConditional logistic regression (matching factors: cohort, age, and date of blood donation) adjusting for BMI