Table 4.
Odds ratios for endometrial cancer associated with androgen and SHBG concentrations on the continuous scale
| All women | Type I endometrial cancer | Age <55 years at diagnosis | Age ≥55 years at diagnosis | Age at diagnosis p-interactionc | |
|---|---|---|---|---|---|
| Total testosterone | |||||
| N cases/controls | 155/284 | 103/189 | 49/86 | 106/198 | |
| OR (95 % CI)a | 1.48 (1.04, 2.12) | 1.46 (0.95, 2.23) | 0.93 (0.55, 1.58) | 2.09 (1.29, 3.39) | |
| p valuea | 0.03 | 0.08 | 0.79 | 0.003 | 0.03 |
| BMI-adjusted OR (95 % CI)b | 1.34 (0.93, 1.94) | 1.31 (0.84, 2.03) | 0.83 (0.47, 1.45) | 2.08 (1.25, 3.44) | |
| BMI-adjusted p valueb | 0.12 | 0.24 | 0.51 | 0.005 | |
| Free testosterone | |||||
| N cases/controls | 130/228 | 87/151 | 47/81 | 83/147 | |
| OR (95 % CI)a | 1.44 (1.10, 1.90) | 1.44 (1.04, 1.99) | 1.03 (0.68, 1.58) | 1.81 (1.25, 2.63) | |
| p valuea | 0.009 | 0.03 | 0.88 | 0.002 | 0.049 |
| BMI-adjusted OR (95 % CI)b | 1.24 (0.92, 1.67) | 1.23 (0.86, 1.75) | 0.92 (0.57, 1.48) | 1.55 (1.04, 2.31) | |
| BMI-adjusted p valueb | 0.16 | 0.25 | 0.73 | 0.03 | |
| DHEAS | |||||
| N cases/controls | 160/300 | 109/205 | 51/93 | 109/207 | |
| OR (95 % CI)a | 1.13 (0.89, 1.44) | 1.12 (0.84, 1.50) | 0.86 (0.59, 1.23) | 1.38 (1.00, 1.90) | |
| p valuea | 0.33 | 0.44 | 0.40 | 0.05 | 0.05 |
| BMI-adjusted OR (95 % CI)b | 1.03 (0.80, 1.32) | 1.01 (0.74, 1.36) | 0.81 (0.55, 1.19) | 1.27 (0.92, 1.76) | |
| BMI-adjusted p valueb | 0.81 | 0.97 | 0.29 | 0.15 | |
| Androstenedione | |||||
| N cases/controls | 159/298 | 108/203 | 50/92 | 109/206 | |
| OR (95 % CI)a | 1.15 (0.78, 1.69) | 1.11 (0.70, 1.75) | 0.66 (0.33, 1.32) | 1.48 (0.93, 2.36) | |
| p valuea | 0.48 | 0.66 | 0.24 | 0.10 | 0.06 |
| BMI-adjusted OR (95 % CI)b | 1.06 (0.71, 1.58) | 0.97 (0.60, 1.57) | 0.62 (0.31, 1.27) | 1.41 (0.86, 2.30) | |
| BMI-adjusted p valueb | 0.78 | 0.89 | 0.19 | 0.17 | |
| SHBG | |||||
| N cases/controls | 136/247 | 93/168 | 49/89 | 87/158 | |
| OR (95 % CI)a | 0.91 (0.81, 1.01) | 0.92 (0.80, 1.04) | 0.98 (0.80, 1.20) | 0.88 (0.77, 1.00) | |
| p valuea | 0.08 | 0.18 | 0.84 | 0.05 | |
| BMI-adjusted OR (95 % CI)b | 0.98 (0.87, 1.11) | 1.00 (0.86, 1.16) | 1.01 (0.81, 1.25) | 0.98 (0.84, 1.14) | |
| BMI-adjusted p valueb | 0.75 | 0.99 | 0.95 | 0.76 | 0.41 |
All analyses were performed on log2 transformed measurements, except SHBG for which square-root transformation was used
aConditional logistic regression (matching factors: cohort, age, and date at blood donation)
bConditional logistic regression (matching factors: cohort, age, and date at blood donation) adjusting for BMI (missing values for BMI were imputed using multiple imputation)
cp-interaction calculated with androgens modeled on the continuous (log2) scale (or square root scale for SHBG)