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. Author manuscript; available in PMC: 2017 May 8.
Published in final edited form as: J Mol Biol. 2015 Nov 10;428(9 Pt B):1897–1911. doi: 10.1016/j.jmb.2015.11.004

Figure 3. MIM-MIT interactions.

Figure 3

(a) Superposition of the MIT domains of human VPS4A (cyan, PDB ID: 2JQH)27, human spastin (pale yellow, PDB ID: 3EAB)80 and mouse katanin (rose, PDB ID: 2RPA)83. (b) Summary of known MIM-MIT interactions between human ESCRT-III proteins and the MIT domains of VPS4A, VPS4B, LIP5 and spastin26; 27; 79; 80; 86; 87; 93; 94; 96; 98; 142. The type of interaction is indicated by shape. The affinity is indicated by fill color. Green outlines denote interactions that have been characterized structurally. “n.d.”, not determined. No ESCRT-III interactions have been reported for katanin or fidgetin. (c) Structure of the human VPS4A MIT domain in complex with the CHMP1B MIM1 (left, PDB ID: 2JQH)94 and the CHMP6 MIM2 (right, PDB ID: 2K3W)26. (d) Structure of the human spastin MIT domain in complex with the CHMP1B MIM3 (right, PDB ID: 3EAB)80. (e) Structure of MIM5-type binding of the C-terminus of CHMP5 to the tandem MIT domain of LIP5 (PDB ID: 2LXM)96.