Figure 5. No motor neuron loss and motor deficits in C9ORF72 transgenic mice with 450 repeats.

(A) Motor performance on a Rotarod measured by latency to fall, (B) hindlimb grip strength, and (C) body weight of 4, 12 and 18 month old wild type (WT), C9^450B and C9^450C mice. (D) Choline Acetyltransferase (ChAT) positive motor neurons detected by immunofluorescence in the anterior horn of lumbar spinal cord of 12 month old WT, C9¹¹⁰ and C9^450C mice. (E) Average number of ChAT-positive neurons per section. Error bars represent s.e.m in n=4–5 animals per group. n.s., not significant using one way ANOVA.

(See also Figure S5).