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. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Cell Stem Cell. 2016 Mar 30;18(5):591–596. doi: 10.1016/j.stem.2016.03.012

Figure 2. Radial glia expression of AXL is conserved in animal models of cortical development and recapitulated in pluripotent stem cell-derived neural progenitors.

Figure 2

(A) Expression of AXL mRNA in the ventricular zone of the developing mouse cerebrum, suggesting that the radial glia expression of AXL is conserved in mouse. (B) Immunostaining of ferret cerebral cortex tissue sections at two neurogenic stages of development reveals conserved expression of AXL at the ventricular edge and in oRG cells (arrows). (C) Immunohistochemistry shows that AXL expression is enriched in radial glia-like cells around the lumen of the ventricular zone-like region of the organoid. Violin plots of single cell gene expression reveals high expression of AXL in choroid plexus-like and radial glia-like cells, but lower expression in neuronal populations. See also Figure S2.