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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Neurobiol Dis. 2016 Mar 18;91:209–220. doi: 10.1016/j.nbd.2016.03.017

Fig. 4.

Fig. 4

Effects of neonatal exposure to sevoflurane and sodium butyrate (NaB) treatment on expression of hippocampal acetylated histones H3 and H4. (A, top) Representative Western blot images of acetyl-H3K9, acetyl-H3K14, and total H3 blots in the hippocampal tissue of rats from four treatment groups. (A, bottom) Histograms showing results of the densitometric analysis of acetyl-H3K9 and acetyl-H3K14 blots in the hippocampal tissue from four treatment groups. Densities of acetyl-H3K9 and acetyl-H3K14 blots in the MS groups were taken as 100%. Acety-H3K9: *P = 0.036 vs. the MS group; #P = 0.048 vs. the Sev group. Acetyl-H3K14: *P = 0.003 vs. the MS group; #P = 0.010 vs. the Sev group. (B) The Western blot data for acetyl-H4, acetyl-H4K5, and acetyl-H4K12 in the hippocampal tissue from four treatment groups presented as in (A). Acetyl-H4: *P = 0.004 vs. the MS group; #P = 0.001 vs. the Sev group. Acetyl-H4K5: *P = 0.001 vs. the MS group; #P = 0.001 vs. the Sev group. Acetyl-H4K12: *P < 0.001 vs. the MS group; #P = 0.004 vs. the Sev group. n = 5 per treatment group. MS: maternal separation; Sev: sevoflurane.