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. Author manuscript; available in PMC: 2018 Jan 1.
Published in final edited form as: Gut. 2015 Oct 15;66(1):107–117. doi: 10.1136/gutjnl-2015-309359

Figure 1. Expression status of oncogenic-candidate snoRNAs in CRC tissues and adjacent normal mucosa in the screening and clinical validation cohorts.

Figure 1

(a) Box plots show expression levels of four snoRNAs (SNORD76, SNORD78, ACA11, and SNORA42) in primary tumor tissues (CRC) and corresponding matched normal mucosa (NM) from eight patients enrolled in the screening cohort. The expression of all snoRNAs was significantly higher in CRC tissues than in adjacent normal mucosa. (p<0.01, Wilcoxon rank correlation test). (b) Box plots show expression levels of four snoRNAs (SNORD76, SNORD78, ACA11, and SNORA42) in CRC (n=192) and NM (n=16) tissues in the clinical validation cohort. Boxes represent interquartile ranges, and the horizontal line across each box indicates median value. The y-axis represents relative expression of four snoRNA, and data were normalized to miR-16 expression. Statistical analysis was performed using Mann-Whitney U tests. All statistical tests were two-sided. **p <0.01; ***p < 0.001