Table 2.

Summary of studies regarding M. genitalium and female infertility.

Source	Study design	Study population	Findings
Clausen et al. [32]	Cross-sectional study	308 women undergoing IVF treatment in Aarhus, Denmark	M. genitalium was detected in 22% of women with tubal factor infertility (TFI) versus 6.3% in women without TFI
Tosh et al. [19]	Multicenter (North America) randomized controlled prospective study, PEACH study	Stored cervical and endometrial specimens of 682 women treated with cefoxitin and doxycycline for clinically suspected PID	M. genitalium was associated with baseline endometritis (AOR 3.0, 95% CI 1.5 to 6.1). Nonsignificant trend towards increased infertility, chronic pelvic pain and recurrent PID, decreased pregnancy, and live birth were found in this study.
Svenstrup et al. [33]	Prospective study	212 couples attending a fertility clinic in Horsens-Brædstrup or the Holstebro fertility clinic in Denmark	M. genitalium was found to be independently associated with TFI (AOR 4.5, 95% CI 1.2–15.6)
Grześko et al. [34]	Prospective study	51 patients with primary infertility (24 women with idiopathic infertility) and 23 women with proven fertility	M. genitalium was found in 19.6% of all infertile women and 4.4% of fertile women (P = 0.156); 29.2% among women with idiopathic infertility versus 4.4% in fertile women (P = 0.0479)