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FP represses isoproterenol-induced fetal gene reactivation in a dose-dependent manner. Intragastric injection of various doses of FP (1–50 mg·kg−1·d−1) for 7 days was followed by continuous infusion with isoproterenol (ISO, 25 mg·kg−1·d−1) for 7 days to experimentally induce heart hypertrophy. Heart tissues were collected and assayed for ANF (a) and β-MHC expression (b). The results are expressed as the means ± SE; n = 10 mice per group (∗ p < 0.05 compared with isoproterenol group).
