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. Author manuscript; available in PMC: 2017 May 5.
Published in final edited form as: Mol Cell. 2016 May 5;62(3):385–396. doi: 10.1016/j.molcel.2016.04.003

Figure 7. Mechanistic summary of the effects of palmitoylation on EGFR activation and signaling.

Figure 7

Palmitoylation of the C-terminus of EGFR promotes membrane association. Palmitoylation of EGFR at C1025 impedes the binding of Grb2 to EGFR whereas palmitoylation at C1122 increases with EGF stimulation and promotes receptor turnover.