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. Author manuscript; available in PMC: 2016 May 8.
Published in final edited form as: J Drug Target. 2015;23(7-8):736–749. doi: 10.3109/1061186X.2015.1065833

Figure 5.

Figure 5

In vivo accumulation of NPs in brain tissue after intravenous injection. A comparison of the percent injected dose of NPs in homogenized brain samples was performed with A) PLGA-DSPE-PEG-RVG and PLGA-DSPE-PEG-RVMAT at 2h post injection, B) PLGA-DSPE-PEG-TGN and PLA-HPG-Ad at 4 h post injection, and C) PLA-HPG-Ad at 24 h post injection. Highly modified PLA-HPG-Ad produced the highest accumulation in the brain at both 4 and 24 h post infusion and was significantly different than untargeted PLA-HPG at both timepoints (n=4). Significance denoted as * (p≤0.05), ** (p≤0.01), *** (p≤0.001).