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Kaplan-Meier survival analysis of CPT-loaded adenosine NPs administered via systemic tail vein delivery in mice with intracranial U87 tumors. Particles were administered via the tail vein A) 3 days post tumor inoculation at a CPT concentration of 4 mg/kg in each dose and B) 5 days post tumor inoculation at a CPT concentration of 10 mg/kg at each dose. For A, n=7 (PLA-HPG CPT and PLA-HPG-Ad CPT), n=6 (Free CPT), n=5 (PBS). For B, n=7 (PLA-HPG CPT), n=5 (PLA-HPG-Ad CPT, Free CPT, PBS).
