Table 1.

Results of ANCOVA analyses, calculated using log time and data from the 0–12 week time points only. Radiation damage to bone was verified by making comparisons between the vehicle groups (Ctrl-VEH vs. RTx-VEH). PTH attenuation of radiation damage was assessed by making comparisons between irradiated groups (RTx-PTH vs. RTx-VEH). Data are reported as p values, with arrows indicating the effect of the independent variables on each outcome measure (↑ indicates an increase, ↑ denotes a decrease)

ANCOVAs		RTx-VEH versus Ctrl-VEH			RTx-PTH versus RTx-Ctrl
		Log time	RTx	Log time × RTx	Log time	PTH	Log time × PTH
Diaphyseal Cortex	BV	0.6384	0.1453	0.1484	0.1622	<0.0001↑	0.0136↑
	TMD	0.1059	0.3550	0.2223	0.1892	0.7162	0.3522
	BMC	0.4036	0.1216	0.1091	0.0915	<0.0001↑	0.0112↑
	Mean thickness	0.0606	0.1788	0.0085↓	0.0207↑	<0.0001↑	0.0017↑
	CSA	0.0975	0.2902	0.1539	0.0102↑	<0.0001↑	0.0202↑
Metaphyseal Trabecular	BV/TV	<0.0001↓	0.4958	<0.0001↓	<0.0001	<0.0001↑	0.6251
	Tb.N	<0.0001↓	0.0007↓	0.0033↓	<0.0001	<0.0001↑	0.7415
	Tb.Th	<0.0001↓	<0.0001↑	0.0829	0.6932	<0.0001↑	0.1926
	Tb.Sp	<0.0001↑	0.0002↑	0.0015↑	<0.0001	0.0002↓	0.2183
	TMD	<0.0001↑	0.0001↑	0.3727	<0.0001↑	0.2719	0.6556
	Conn.D	<0.0001↓	0.3731	<0.0001↓	<0.0001↓	<0.0001↑	0.2876
	SMI	<0.0001↑	<0.0001↑	<0.0001↑	<0.0001↑	<0.0001↓	0.0337↓
	DA	0.1023	<0.0001↓	0.0006↓	0.0090↓	0.0132↑	0.3944
Distal 5 mm	BV	0.0030↓	<0.0001↑	0.3640	0.5934	<0.0001↑	0.0065↑
	TMD	<0.0001↑	0.0716	0.0032↑	<0.0001↑	0.0279↓	0.4786
	BMC	0.2376	<0.0001↑	0.2179	0.0021↑	<0.0001↑	0.0025↑
Axial Compression	Ultimate load	<0.0001↓	0.9637	0.0123↓	<0.0001↑	<0.0001↑	0.6334
	Work	<0.0001↓	0.8309	<0.0001↓	<0.0001↓	<0.0001↑	0.5203
	Stiffness	0.0024↑	0.1006	0.0004↑	<0.0001↑	0.8066	0.7059
	Apparent strength	<0.0001↓	0.0135↑	0.0021↑	<0.0001↓	<0.0001↑	0.2456