Figure 2.

Serum concentration of thromboxane B₂ after a single oral dose of riociguat 2.5 mg, 2 daily doses of aspirin 500 mg, or 2 daily doses of aspirin with coadministration of riociguat and the second daily dose of aspirin. Measurements were taken before the initial aspirin dose (t = −24 hours); before administration of riociguat and/or a second aspirin dose (t = 0; baseline); and 24, 48, and 72 hours after completion of each treatment regimen. Data are shown as geometric means and plotted on a semilogarithmic scale. LLOQ: lower limit of quantification.