Table 4.
Point estimates (least squares means) and 2-sided 90% confidence intervals (CIs) for the ratio (riociguat plus aspirin treatment)/(riociguat treatment) calculated for selected pharmacokinetic parameters in participants receiving a single morning dose of riociguat 2.5 mg, aspirin 500 mg on 2 consecutive mornings, or both treatments concomitantly (n = 15)
| Analyte and parameter | Point estimate | 90% CI | CV, % |
|---|---|---|---|
| Riociguat | |||
| AUC | 0.964 | 0.868–1.07 | 16 |
| Cmax | 0.853 | 0.780–0.933 | 14 |
| Metabolite M1 | |||
| AUC | 1.04 | 0.960–1.14 | 13 |
| Cmax | 1.04 | 0.928–1.16 | 17 |
Note
AUC: area under the plasma concentration–time curve from time 0 to infinity; Cmax: maximum concentration in plasma; CV: coefficient of variation (intraindividual).