Table 5.
Point estimates (least squares means) and 2-sided 90% confidence intervals (CIs) of fraction unbound for the ratio (riociguat plus aspirin treatment)/(riociguat treatment) in participants receiving a single morning dose of riociguat 2.5 mg, aspirin 500 mg on 2 consecutive mornings, or both treatments concomitantly (n = 15)
| Analyte and time point | Point estimate | 90% CI |
|---|---|---|
| Riociguat | ||
| 1 | 1.19 | 1.07–1.33 |
| 8 | 1.06 | 0.966–1.17 |
| Metabolite M1 | ||
| 1 | 1.24 | 1.12–1.37 |
| 8 | 1.05 | 0.978–1.13 |
Note
Time points are hours after riociguat administration.