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Clearance of riociguat by metabolism to M1 in studies 1 and 3 with smokers (a) and studies 2 and 4 with nonsmokers (b). Boxes represent 25th–75th percentiles, horizontal lines represent medians, and error bars represent 5th–95th percentiles. CrCL: creatinine clearance; M1: main metabolite of riociguat.
