Table 3.
Baseline demographic characteristics of healthy individuals (normal hepatic function; controls) and patients with mild (Child-Pugh A) or moderate (Child-Pugh B) hepatic impairment who were valid for pharmacokinetic analysis (total population of smokers and nonsmokers)
| Demographic characteristic | Child-Pugh A (n = 16) | Child-Pugh B (n = 16) | Control A (n = 16) | Control B (n = 16) | Total (N = 64) |
|---|---|---|---|---|---|
| Age,a years | 55.3 (42.0–72.0) | 56.7 (39.0–70.0) | 52.3 (35.0–69.0) | 56.1 (37.0–67.0) | 55.1 (35.0–72.0) |
| Female, no. (%) | 5 (31) | 6 (38) | 5 (31) | 6 (38) | 22 (34) |
| White, no. (%) | 16 (100) | 16 (100) | 16 (100) | 16 (100) | 64 (100) |
| BMIb | 27.2 (4.0) | 26.8 (3.4) | 27.6 (3.1) | 27.3 (2.1) | 27.2 (3.2) |
| CLCR,b mL/min | 90.1 (23.0) | 79.0 (20.0) | 94.2 (19.9) | 85.8 (17.1) | Not calculated |
| Current smoker, no. (%) | 3 (19) | 5 (31) | 2 (13) | 2 (13) | 12 (19) |
Note
BMI: body mass index; CLCR: creatinine clearance.
a
Arithmetic mean (range).
b
Arithmetic mean (standard deviation).