Table S2.
Midazolam study: pharmacokinetic parameters of riociguat and M1 in smokers and nonsmokers
| Nonsmokers (n = 12) | Smokers (n = 10) | |||||||
|---|---|---|---|---|---|---|---|---|
| Riociguat | M1 | Riociguat | M1 | |||||
| Parameter | Geometric mean (range) |
CV, % | Geometric mean (range) |
CV, % | Geometric mean (range) |
CV, % | Geometric mean (range) |
CV, % |
| AUC(T1-T2) ss, μg·h/L | 692.8 (471.5–1,245.2) | 34.5 | 379.5 (132.0–747.5) | 45.0 | 215.0 (66.2–667.6) | 94.2 | 633.5 (445.6–1,015.2) | 29.3 |
| Cmax ss, μg/L | 116.5 (83.9–193.8) | 28.3 | 56.3 (20.4–104.4) | 43.7 | 59.6 (28.6–152.7) | 58.4 | 95.1 (67.2–160.4) | 28.5 |
| tmax ss, hours | 3.0 (1.0–4.0) | … | 4.0 (2.0–4.0) | … | 1.0 (0.5–4.0) | … | 4.0 (1.0–4.0) | … |
Note
Data are means, except tmax ss which is a median. AUC(T1-T2) ss: area under T1-T2 of the plasma concentration–time curve at steady state; Cmax ss: maximum plasma concentration at steady state; CV: coefficient of variation; tmax ss: time to reach Cmax ss.