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. 2016 Mar;6(1):82–92. doi: 10.1086/685023

Figure 5.

Figure 5

Inhibition of cytochrome P450 1B1 (CYP1B1) with 2,3′,4,5′-tetramethoxystilbene (TMS) does not reverse monocrotaline (MCT)-induced PH yet improves survival. Female and male rats were given a single dose of MCT (60 mg/kg subcutaneously) and 14 days later were given TMS (3 mg/kg/day intraperitoneally) or vehicle (∼5% ethanol in saline) for an additional 14 days and then assessed for indices of PH. A, Right ventricular systolic pressures (RVSP) as assessed by jugular vein cannulation; n = 5–11. B, Right ventricular hypertrophy as assessed by ratio of the weight of the right ventricle (RV) to the combined weight of the left ventricle and septum (LV+S); n = 9–14. C, Heart rate; n = 6–12. D, Kaplan-Meier survival analysis in rats treated with MCT (total of 16 animals per group at the start of the experiment). Data were analyzed by a 1-way analysis of variance followed by a Tukey post hoc test. *P < 0.05; **P < 0.01; ***P < 0.001, vehicle versus MCT; #P < 0.05, male versus female.