Figure 3.

A, B, Example of an arterial-venous-segmented vascular tree is shown for a patient with CTEPH (A) and a control subject (B), with the arterial phase shown in blue and the venous phase shown in red. C–F, The proximal vasculature (C, D) and the distal vasculature (E, F), separated by size, are shown under the respective images. Note the loss of smaller vessels in E, in comparison with F, and the dilation of the large proximal vasculature in the arterial, as compared to venous, proximal vessels in C. G, Relative volume distribution profiles combined for each cohort for both the arterial (top) and venous (bottom) phases. Note the rightward shift of the vascular profile in the subjects with CTEPH (black lines) compared to controls (red lines), as also demonstrated in Figure 2. In the arterial system, the CTEPH cohort also has increased distribution in the large vessels (cross-sectional area > 10 mm²). H, Comparisons of large vessels (BV>10) and small vessels (BV5) are shown for both groups, highlighting the difference in arterial/venous (Art/Vein) ratios in the two different vessel sizes. BV5: blood vessel volume for vessels with a cross-sectional area ≤ 5 mm²; BV>10: blood vessel volume for vessels with a cross-sectional area > 10 mm²; CTEPH: chronic thromboembolic pulmonary hypertension.