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. 2016 May 9;6:25694. doi: 10.1038/srep25694

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Copyright © 2016, Macmillan Publishers Limited

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Doxorubicin accumulation fluorescence in (A) SW620 and SW620/Ad300 cells, (B) HEK293/pcDNA3.1 and HEK/ABCB1 cells pretreated or non-pretreated with bafetinib at 3 μM. Mitoxantrone accumulation fluorescence in (C) NCI-H460 and NCI-H460/MX20 cells, (D) HEK293/pcDNA3.1 and HEK/ABCG2-R482 cells pretreated or non-pretreated with bafetinib at 3 μM. Scale bar, 10 μm. The effects of bafetinib on accumulation of [³H]-paclitaxel in (E) SW620 and SW620/Ad300 cells, (F) HEK293/pcDNA3.1 and HEK/ABCB1 cells. Effects of bafetinib on accumulation of [³H]-mitoxantrone in (G) NCI-H460 and NCI-H460/MX20 cells, (H) HEK293/pcDNA3.1 and HEK/ABCG2-R482 cells. Error bars represent the SD. *p < 0.05 versus the control group. Verapamil 3 μM or FTC 3 μM is used as positive control for ABCB1- or ABCG2-overexpressing cells respectively.