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. Author manuscript; available in PMC: 2016 Jul 13.
Published in final edited form as: ACS Biomater Sci Eng. 2015 May 26;1(7):463–480. doi: 10.1021/acsbiomaterials.5b00122

Figure 7.

Figure 7

Templated bone formation by PLA-PEG-PLA/HA (HA-PELA) scaffolds in critical-size rat femoral defects. (A) Microcomputed tomography (µ-CT) reconstructions of rat femoral defects treated with spiral-wrapped electrospun HA-PELA scaffolds immediately post-op or after 12 weeks. Treatment groups are the HA-PELA scaffold alone, HA-PELA with rat MSCs, or HA-PELA with 500 ng of rhBMP-2. (B) Two-dimensional bone mineral density color maps of the scaffold-filled defect over time (red representing higher mineral density). Longitudinal (top) and axial (bottom) midslices of the defect treated with HA−PELA immediately post-op, and HA−PELA, HA−PELA + MSCs, and HA−PELA + 500 ng rhBMP-2 at 4 and 12 weeks post-op. Bone formation that matches the spiral template of the scaffold is visible in the HA-PELA + MSCs treatment group. Scale bars = 1 mm. Adapted with permission from ref. 136. Copyright 2015 American Chemical Society.