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. Author manuscript; available in PMC: 2017 Apr 5.
Published in final edited form as: J Am Coll Cardiol. 2016 Apr 5;67(13):1544–1552. doi: 10.1016/j.jacc.2016.01.045

Central Illustration. H2-receptor antagonists and heart failure: Unadjusted associations between H2 receptor antagonists (H2RA) use and heart failure.

Central Illustration

(A) unadjusted Kaplan-Meier cumulative event curve for incident heart failure in all participants, (B) locally weighted scatterplot smoothing (LOWESS) comparing incident heart failure occurring at any point during follow-up relative to the baseline predicted risk of heart failure (predicted by the ARIC heart failure score), (C) unadjusted Kaplan-Meier cumulative event curve for incident heart failure in participants at LOW risk for heart failure (predicted by an ARIC heart failure score ≤ 11), (D) and unadjusted Kaplan-Meier cumulative event curve for incident heart failure in participants at HIGH risk for heart failure (predicted by an ARIC heart failure score >11)

ARIC = Atherosclerosis Risk in Communities.