Table 1. Baseline Characteristics.
| H2RA Users (n = 313) | H2RA Nonusers (n = 6,065) | p Value | |
|---|---|---|---|
| Age, yrs | 65.2 ± 9.9 | 62.1 ± 10.2 | <0.001 |
| Female | 52.1 | 52.7 | 0.84 |
| Race | |||
| White | 43.8 | 37.6 | |
| Chinese | 8.0 | 12.5 | 0.008 |
| African-American | 23.3 | 28.0 | |
| Hispanic | 24.9 | 21.9 | |
| Height, cm | 165.8 ± 9.8 | 166.3 ± 10.0 | 0.44 |
| Weight, kg | 80.3 ± 16.7 | 78.5 ± 17.4 | 0.06 |
| Body mass index, kg/m2 | 29.2 ± 5.6 | 28.3 ± 5.5 | 0.005 |
| Educational attainment | |||
| No high school degree | 18.5 | 18.2 | |
| High school degree | 22.4 | 17.8 | |
| Some college | 17.6 | 16.2 | 0.26 |
| Bachelor's degree | 17.6 | 17.5 | |
| Higher than bachelor's degree | 13.4 | 18.2 | |
| Cigarette smoking status | |||
| Never | 48.9 | 51.0 | |
| Former | 39.0 | 36.2 | 0.62 |
| Current | 12.1 | 12.8 | |
| Pack-years | 16.3 ± 26.6 | 11.0 ± 20.4 | <0.001 |
| Hypertension | 54.0 | 44.8 | 0.002 |
| Systolic blood pressure, mm Hg | 129.3 ± 20.4 | 126.5 ± 21.6 | 0.03 |
| Diabetes mellitus | 14.4 | 13.6 | 0.71 |
| Cholesterol, mg/dl | 192 (169-214) | 192 (170-215) | 0.46 |
| Glucose, mg/dl | 91 (84-101) | 90 (83-99) | 0.11 |
| NT-proBNP, pg/ml* | 66 (30-121) | 54 (24-112) | 0.02 |
| Medications | |||
| NSAIDs | 54.3 | 40.1 | <0.001 |
| Oral steroids | 3.8 | 1.4 | 0.003 |
| Beta-blockers | 12.8 | 9.4 | 0.001 |
| ACE inhibitors/ARBs | 25.6 | 18.0 | 0.001 |
| Any diuretic | 19.2 | 13.3 | 0.005 |
Values are mean ± SD, percentage, or median (interquartile range); differences were evaluated with Student t test, Fisher exact test, or Wilcoxon rank sum test respectively.
*
Available for 5,285 participants.
ACE = angiotensin-converting enzyme; ARB = angiotensin II receptor blocker; H2RA = H2 receptor antagonist; NSAIDs = nonsteroidal anti-inflammatory drugs; NT-proBNP = N-terminal pro–B-type natriuretic peptide.