Table 3. Consistency of H2RA Use and LV Changes*.
| Change in LV Parameters Relative to Baseline Exam (n = 2,806) | ||
|---|---|---|
| Change | 95% CI | |
| Change in LV end-diastolic volume | ||
| No H2RA use | -10.9 ml | -11.7 to -10.0 mL |
| H2RA use at only 1 study exam | -8.8 ml | -14.4 to -3.2 mL |
| Consistent H2RA use at 4+ study exams | 0.8 ml | -8.1 to 9.6 mL |
| Test of trend: | p = 0.02 | |
| Change in LV ejection fraction | ||
| No H2RA use | -0.7% | -1.0 to -0.4 |
| H2RA use at only 1ne study exam | -0.1% | -1.9 to 1.8 |
| Consistent H2RA use at 4+ study exams | 0.0% | -3.0 to 2.9 |
| Test of trend: | p = 0.61 | |
| Change in LV stroke volume | ||
| No H2RA use | -8.3 ml | -9.0 to -7.7 |
| H2RA use at only 1 study exam | -5.8 ml | -10.1 to -1.5 |
| Consistent H2RA use at 4+ study exams | -0.8 ml | -7.6 to 5.9 |
| Test of trend: | p = 0.04 | |
| Change in LV mass | ||
| No H2RA use | 2.9 g | 2.2 to 3.6 g |
| H2RA use at only 1 study exam | 0.7 g | -3.8 to 5.2 g |
| Consistent H2RA use at 4+ study exams | 6.3 g | -0.8 to 13.3 |
| Test of trend: | p = 0.60 | |
| Change in LV Mass/Volume Ratio | ||
| No H2RA use | 0.12 g/ml | 0.11 to 0.13 |
| H2RA use at only one study exam | 0.08 g/ml | 0.03 to 0.13 |
| Consistent H2RA use at 4+ study exams | 0.04 g/ml | -0.03 to 0.12 |
| Test of trend: | p = 0.02 | |
*
Changes between the initial and the follow-up cardiac magnetic resonance imaging (CMR) exam.
All models fully adjusted for age, sex, race/ethnicity, height, weight, study site, the sum of the left ventricular (LV) parameter of interest at CMR 1 and CMR 2, education, cigarette smoking, pack-years, hypertension, systolic blood pressure, diabetes, cholesterol, glucose, and daily exercise.