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. 2016 May 9;6:25582. doi: 10.1038/srep25582

Figure 3. The number of segments from depth coverage of the sequencing data.

Figure 3

(a) The numbers of segments from WGS data for 37 GBM samples are shown when BIC-seq was applied with a parameter λ ranging from 1.0 to 5.0. Each bar represents the number of segments of an individual sample and samples are ordered by the numbers of segments with λ = 1.0. Because the numbers of segments increase when values for λ decrease, bars are segmented with the numbers of segments with λ = 5.0 (dark blue) and the increased numbers of segments with the changes of λ from 5.0 to 4.0 (blue), from 4.0 to 3.0 (sky-blue), from 3.0 to 2.0 (orange), and from 2.0 to 1.0 (red). (b) The numbers of segments of level 3 SNP array data from TCGA for the same samples are shown, sorted in the same order as (a). (c) The numbers of segments for the same samples are shown when WIFA-Seq was applied to WGS data. When the noise threshold C increases, the numbers of segments for all the samples dramatically decreased.