FIG. 6.

Spatial learning in the Morris water maze. Female mice swam faster than male mice during both standard and reversal training trials (A). Mice with mild CCI had equivalent learning abilities to sham controls (B), but all mice with severe CCI were impaired in their ability to learn the location of a hidden platform in the Morris water maze, during both standard training and reversal training trials (C). Brain-injured mice and sham-treated mice are represented by broken lines and solid lines, respectively. Asterisks (*; A) denote faster swimming speeds of female mice; pound sign (#; C) represents poorer performance of mice with severe CCI, compared to sham controls, on the denoted training days. CCI, controlled cortical impact.