Table 1.
Sham (%) | Mild CCI (%) | Severe CCI (%) | Summary (%) | ||||
---|---|---|---|---|---|---|---|
Male | Female | Male | Female | Male | Female | Mean±SEM | |
Open field—distance traveled | 16.5 | 13.6 | 14.2 | 21.9 | 15.2 | 19.8 | 16.9±1.3 |
Open field—speed while mobile | 8.3 | 8.7 | 8.8 | 10.7 | 10.4 | 9.4 | 9.4±0.4 |
Open field—no. of mobile episodes | 13.9 | 13.2 | 15.3 | 22.9 | 24.9 | 27.4 | 19.6±2.5 |
Open field—center distance | 17.2 | 17.2 | 15.1 | 18.1 | 13.7 | 21.2 | 17.1±1.1 |
Open field—rearing | 47.1 | 37.7 | 37.7 | 49.8 | 50.3 | 59.8 | 47.0±3.4 |
Rotarod—latency to fall | 20.7 | 12.8 | 23.5 | 19.5 | 23.2 | 31.4 | 21.8±2.5 |
Y-maze—% alternations | 14.9 | 16.9 | 23.4 | 13.7 | 11.5 | 19.8 | 16.7±1.8 |
Y-maze—distance traveled | 24.1 | 13.7 | 30.7 | 18.1 | 32.1 | 16.1 | 22.5±3.2 |
MWM (standard)—speed | 14.1 | 9.4 | 11.1 | 10.3 | 12.4 | 13.7 | 11.8±0.8 |
MWM (reversal)—speed | 12.8 | 9.3 | 10.4 | 12.6 | 22.1 | 12.0 | 13.2±1.9 |
MWM (standard)—distance to platform | 24.7 | 19.4 | 26.4 | 17.6 | 20.3 | 15.6 | 20.7±1.7 |
MWM (reversal)—distance to platform | 25.5 | 26.4 | 27.8 | 42.0 | 20.3 | 23.3 | 27.6±3.1 |
MWM probe (standard)—NW time | 26.9 | 47.2 | 31.3 | 41.8 | 32.2 | 28.8 | 34.7±3.3 |
MWM probe (reversal)—SE time | 21.0 | 28.9 | 31.0 | 27.9 | 45.1 | 31.1 | 30.8±3.2 |
MWM probe (standard)—island crossings | 42.7 | 53.0 | 53.1 | 50.4 | 71.4 | 44.1 | 52.5±4.2 |
MWM probe (reversal)—island crossings | 51.8 | 51.3 | 52.5 | 62.4 | 82.5 | 58.7 | 59.9±4.9 |
MWM probe (standard)—island time | 46.3 | 63.9 | 68.7 | 55.0 | 77.0 | 48.5 | 59.9±4.9 |
MWM probe (reversal)—island time | 59.6 | 56.6 | 61.4 | 68.4 | 87.7 | 64.9 | 66.4±4.6 |
Mean | 27.1 | 27.7 | 30.1 | 31.3 | 36.2 | 30.3 | |
SEM | 3.6 | 4.4 | 4.3 | 4.5 | 6.2 | 4.1 |
No statistical differences in mean variation were observed between levels of injury or sex.
MWM, Morris water maze; CCI, controlled cortical impact; NW, northwest; SE, southeast; SEM, standard error of the mean.