Table 1.

Model parameters

Costs
	Cost	Sensitivity analysis	Reference
Drug costs
ADA, cost per 40 mg syringe	$1748	$1000–$3000	16
IFX, cost per 100 mg unit	$1114	$500–$1500	16
VDZ, cost per 300 mg dose	$5788	$3000–$9000	16
Facility costs
Administration cost of ADA intramuscular injection	$27	–	17
Administration cost of a 3 h IFX infusion	$116	–	17
Administration cost of a 1 h VDZ infusion	$75	–	17
Transition probabilities
	Probability	Sensitivity analysis	Reference
ADA
Mucosal healing at 8 weeks, 80 mg dosing	0.2718	0.1–0.5	18–21
Mucosal healing at 8 weeks, 160 mg dosing	0.3564	0.2–0.6	18–21
Mucosal healing at 52 weeks, given week 8 mucosal healing	0.3078	0.2–0.6	18–21
Mucosal healing at 52 weeks, given week 8 active disease	0.0993	0.05–0.3	18–21
IFX
Mucosal healing at 52 weeks	0.3688	0.2–0.6	22 23
VDZ
Clinical response at 6 weeks	0.4116	0.1–0.5	24 25
Mucosal healing at 52 weeks, given week 6 response	0.4489	0.2–0.6	24 25
Mucosal healing at 52 weeks, given week 6 non-response	0.1480	0.05–0.3	24 25

ADA, adalimumab; IFX, infliximab; VDZ, vedolizumab.