Table 2.
Drugs associated with a known or possible risk of torsades de pointes3
| Drug class | Known risk | Possible risk |
|---|---|---|
| Alpha-blocker | Alfuzosin | |
| Anesthetic, general | Propofol Sevoflurane |
|
| Antiarrhythmic | Amiodarone Disopyramide Dofetilide Flecainide Ibutilide Procainamide Quinidine Sotalol |
|
| Anticonvulsant | Felbamate | |
| Antidepressant | Citalopram Escitalopram |
Clomipramine Desipramine Imipramine Lithium Mirtazapine Nortriptyline Trimipramine Venlafaxine |
| Anticancer | Arsenic trioxide Eribulin Vandetanib |
Bortezomib Bosutinib Certinib Crizotinib Dabrafenib Dasatanib Lapatanib Nilotinib Pazopanib Sorafenib Sunitinib Vemurafenib Tamoxifen Panobinostat Vorinostat |
| Antiemetic | Ondansetron Droperidol |
Dolasetron Granisteron Promethazine |
| Antifungal | Fluconazole Pentamidine |
|
| Antihypertensive | Isradipine Moexipril/hydrochlorothiazide Nicardipine |
|
| Antimalarial | Chloroquine Halofantrine |
Artenimol/piperaquine |
| Antipsychotics | Chlorpromazine Haloperidol Pimozide Thioridazine |
Aripiprazole ClozapineIloperidone Olanzapine Paloperidone Quetiapine Risperidone Sertindole Ziprasidone |
| Antibiotic | Azithromycin Clarithromycin Erythromycin Ciprofloxacin Levofloxacin Moxifloxacin |
Bedaquiline Gemifloxacin Norfloxacin Ofloxacin Telavancin Telithromycin |
| Antiviral | Atazanavir Foscarnet Rilpivirine Saquinavir |
|
| Antispasmodic | Mirabegron | |
| Cholinesterase inhibitor | Donepezil | |
| Dopamine agonist | Apomorphine | |
| Estrogen agonist/antagonist | Toremifene | |
| Gonadotropin receptor agonist/antagonist | Leuprolide | |
| Gonadotropin-releasing hormone agonist/antagonist | Degarelix | |
| Histamine H2 receptor antagonist | Famotidine | |
| Immunosuppressant | Tacrolimus | |
| Illicit drugs | Cocaine | |
| Muscle relaxants | Tizanidine Tolterodine |
|
| Norepinephrine reuptake inhibitor | Atomoxetine | |
| Oxytocic | Oxytocin | |
| Opiates | Methadone | |
| Phosphodiesterase 3 inhibitors | Anagrelide Cilostazol |
|
| Phosphodiesterase 5 inhibitors | Vardenafil | |
| Progesterone antagonist | Mifepristone | |
| Sedative | Dexmedetomidine | |
| Somatostatin analog | Pasireotide | |
| Sphingosine phosphate receptor modulator | Fingolimod |