Table 1. Gene ontology (GO) classification of human proteins with poly-Asp sequence motifs.
| Description | No. of proteins | P-value |
|---|---|---|
|
Proteins containing a D4 sequence
| ||
| Total no. of proteins | 306 | |
| Mapped with GO classification | 185 | |
| Nuclear proteins | 86 | 6.76×10−10 |
| Regulation of gene expression | 51 | 6.71×10−5 |
| Nucleic acid binding | 52 | 1.80×10−3 |
|
Proteins containing a D5 sequence
| ||
| Total no. of proteins | 118 | |
| Mapped with GO classification | 68 | |
| Nuclear proteins | 34 | 4.66×10−5 |
| Nucleic acid binding | 22 | 2.86×10−2 |
| Chromosome organization | 9 | 3.50×10−3 |
|
Proteins containing a D6 sequence
| ||
| Total no. of proteins | 50 | |
| Mapped with GO classification | 29 | |
| Nuclear proteins | 16 | 2.00×10−3 |
| Transcription regulator | 9 | 8.80×10−3 |
| Gene expression | 13 | 1.54×10−2 |
A major proportion of proteins are associated with nuclear function and gene expression (prepared using Gene set analysis toolkit V2 http://bioinfo.vanderbilt.edu/webgestalt/).