Table 2.
Basic patient characteristics stratified according to Charlson Comorbidity Index (CCI) subgroups.
| CCI category | Overall | 0 | 1 | 2 | 3 | 4 | 5-8 | p-value |
|---|---|---|---|---|---|---|---|---|
| n (%) | 37,288 (100) | 25,739 (69.0) | 7,986 (21.4) | 2,402 (6.4) | 687 (1.8) | 299 (0.8) | 165 (0.4) | |
| Mean age, years (SDa) | 57.7 (14.5) | 55.3 (14.6) | 62.1 (12.5) | 65.4 (12.4) | 66.5 (12.1) | 65.3 (11.8) | 65.2 (11.4) | <0.001 |
| Male, n (%) | 19,660 (52.7) | 12,681 (49.2) | 4,728 (59.2) | 1,493 (62.2) | 435 (63.3) | 207 (69.2) | 116 (70.3) | <0.001 |
| History of cancer, n (%) | 4,299 (11.5) | 2,900 (11.3) | 899 (11.3) | 328 (13.7) | 94 (13.7) | 53 (17.7) | 25 (15.2) | <0.001 |
| Histological grade of tumor differentiation, n (%) | <0.001 | |||||||
| well | 5,095 (13.7) | 3,610 (14) | 1,069 (13.4) | 283 (11.8) | 74 (10.8) | 43 (11.4) | 16 (9.7) | |
| moderately | 17,005 (45.7) | 11,406 (44.3) | 3,840 (48.1) | 1,185 (49.3) | 339 (49.3) | 150 (50.2) | 85 (51.5) | |
| poorly | 8,782 (23.6) | 5,745 (22.3) | 2,044 (25.6) | 680 (28.3) | 194 (28.2) | 79 (26.4) | 40 (24.2) | |
| unclassified | 6,406 (17.2) | 4,988 (19.5) | 1,033 (12.9) | 254 (10.6) | 80 (11.6) | 27 (9) | 24 (14.5) | |
| Tumor stage, n (%) | 0.005 | |||||||
| localized | 18,820 (50.5) | 12,949 (50.3) | 3,986 (49.9) | 1,259 (52.4) | 386 (56.2) | 159 (53.2) | 81 (49.1) | |
| regional | 14,440 (38.7) | 10,036 (39) | 3,138 (39.3) | 882 (36.7) | 221 (32.2) | 102 (34.1) | 61 (37.0) | |
| advanced | 2,742 (7.4) | 1,841 (7.1) | 619 (7.8) | 184 (7.7) | 54 (7.9) | 27 (9.0) | 17 (10.3) | |
| unclassified | 1,286 (3.4) | 923 (3.6) | 243 (3.0) | 77 (3.2) | 26 (3.8) | 11 (3.7) | 6 (3.6) | |
| ASAb score, n (%) | <0.001 | |||||||
| 1-2 | 25,548 (68.5) | 19,821 (77.0) | 4,569 (57.2) | 860 (35.8) | 185 (26.9) | 76 (25.4) | 27 (16.4) | |
| 3-5 | 11,740 (31.5) | 5,918 (22.9) | 3,417 (42.8) | 1,542 (64.2) | 502 (73.1) | 223 (74.6) | 138 (83.6) | |
| ECOGc scale, n (%) | <0.001 | |||||||
| 0 | 15,140 (40.6) | 11,480 (44.6) | 2,686 (33.6) | 666 (27.7) | 187 (27.2) | 78 (26.1) | 43 (26.1) | |
| 1 | 15,117 (40.5) | 11,313 (43.9) | 3,604 (45.1) | 124 (5.2) | 43 (6.3) | 24 (8.0) | 9 (5.5) | |
| 2 | 5,017 (13.5) | 2,707 (10.5) | 1,485 (18.6) | 579 (24.1) | 150 (21.8) | 63 (21.1) | 33 (20.0) | |
| 3-4 | 2,014 (5.4) | 249 (0.9) | 211 (2.7) | 1,033 (43.0) | 307 (44.7) | 134 (44.8) | 80 (48.4) | |
| Admission from emergency department, n (%) | 5,134 (13.8) | 2,752 (10.7) | 1,463 (18.3) | 561 (23.4) | 196 (28.5) | 95 (31.8) | 67 (40.6) | <0.001 |
| Primary cancer site, n (%) | <0.001 | |||||||
| Breast, Thyroid | 5,782 (15.5) | 4,770 (18.5) | 828 (10.4) | 144 (6.0) | 27 (3.9) | 9 (3.0) | 4 (2.4) | |
| CRCd, GYNe, GUf | 16,261 (43.6) | 11,200 (43.5) | 3,449 (43.2) | 1,121 (46.7) | 304 (44.3) | 126 (42.1) | 61 (37.0) | |
| HNg, Thorax | 8,727 (23.4) | 6,403 (24.9) | 1,746 (21.9) | 410 (17.1) | 107 (15.6) | 42 (14.0) | 19 (11.5) | |
| HPBh, Stomach, Small bowel | 5,829 (15.6) | 2,872 (11.2) | 1,839 (23.0) | 682 (28.4) | 239 (34.8) | 118 (39.5) | 79 (47.9) | |
| CNSi | 689 (1.8) | 504 (2.0) | 124 (1.6) | 45 (1.9) | 10 (1.5) | 4 (1.3) | 2 (1.2) | |
aStandard deviation; bAmerican Society of Anesthesiologist; cEastern Cooperative Oncology Group; dColorectum; eGynecological; fGenitourological gHead and neck; hHepato pancreatico biliary; iCentral nervous system.