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. 2016 Apr 28;7(7):862–871. doi: 10.7150/jca.14440

Figure 4.

Figure 4

PCR array analysis of candidate ANG target genes, ANG regulates HMGA2 expression in SK-MES-1s. A, Names of the 84 proliferation, migration, and invasion related genes. B, Heat map of the variations in the expression of the 84 genes between Ad-ANG and Ad-GFP SK-MES-1s. C, HMGA2 mRNA levels were significantly higher in cancerous tissues than in adjacent normal tissues in SQCLC patients (n = 3 experiments for all tests). * P < 0.05 versus adjacent normal. D, HMGA2 mRNA expression was activated in Ad-ANG SK-MES-1s (n = 3 for each cell group). * P < 0.05 versus control. E, HMGA2 mRNA expression was decreased in shANG SK-MES-1s, as compared with shScramble SK-MES-1s (n = 3 for each cell group). * P < 0.05 versus control. F, ICC results showed that HMGA2 expression levels were decreased in the nucleus of shANG SK-MES-1s. All experiments were carried out in triplicate.