Table 1. AdoMet-dependent tRNA methyl transferases in E. coli.
References for each enzyme are as follows: EcTrmA (Ny and Bjork, 1980), EcTrmB (De Bie et al., 2003), EcTrmC (Taya and Nishimura, 1973), EcTrmD (Bystrom and Bjork, 1982b), EcTrmH (Persson et al., 1997), EcTrmJ (Purta et al., 2006), EcTrmL (Benitez-Paez et al., 2010), EcTrmM (Golovina et al., 2009), and EcTrmO (Kimura et al., 2014). Note that EcTrmO has a unique single-sheeted β-barrel structure that does not belong to any of the 5 known classes of methyl transferases and is designated as class VIII (Kimura et al., 2014). Only the first reference is given for each enzyme.
| Enzyme (Synonyms) |
Modification | Chemical structure | Class | Enzyme (Synonyms) |
Modification | Chemical structure | Class |
|---|---|---|---|---|---|---|---|
| TrmA (rT) |
m5U54 (T54) |  |
I | TrmJ (YfhQ) |
Cm32/Um32 |  |
IV |
| TrmB (TrmI, YggH) |
m7G46 |  |
I | TrmL (YibK) |
Cm34/ cmnm5Um34 |
 |
IV |
| TrmC (MnmC, YfcK) |
mnm5s2U34 |  |
I | ||||
| TrmD | m1G37 |  |
IV | TrmM (YfiC) |
m6A37 |  |
I |
| TrmH (SpoU) |
Gm18 |  |
IV | TrmO (TsaA, YaeB) |
m6t6A37 |  |
VIII |