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. 2015 Dec 8;1:15040. doi: 10.1038/celldisc.2015.40

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Copyright © 2015 SIBS, CAS

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In vitro bioimmunity of TERT mRNA delivery CD19 CAR-modified T cells. (a–d) Cytokine release of TERT mRNA delivery to CD19 CAR-modified T cells was detected by enzyme-linked immunosorbent assay after co-culture with CD19⁺ tumor cells at different E/T ratio (1:1, 10:1, 25:1), and four types of cytokines (IL-2, IL-10, IFN-γ and TNF-α) were detected. The data are presented as the mean±s.d. of results from three independent experiments. *P<0.05, ***P<0.001. (e) CD19-specific CTL of TERT mRNA delivery to CD19 CAR-modified T cells by flow cytometry. Raji cells are CD19⁺ human Burkitt’s lymphoma cells, and K562 cells are CD19⁻ human lymphoma cells. (f) Cytolytic activity was determined after 4 h of co-culture. The data are presented as the mean±s.d. of results from three independent experiments. *P<0.05, ***P<0.001.