Table 2.
Measures of cardiac remodelling, valve severity and exercise capacity for each valve lesion stratified by BNP
| Controls | Aortic stenosis |
Mitral stenosis |
Aortic regurgitation |
Mitral regurgitation |
||
|---|---|---|---|---|---|---|
| Number of subjects | Normal BNP | 34 | 24 | 10 | 29 | 21 |
| High BNP | 5 | 10 | 20 | 10 | 12 | |
| Total | 39 | 34 | 30 | 29 | 33 | |
| NYHA class 2, n (%) | Normal BNP | 1 (2.9) | 8 (33.3) | 3 (33.3) | 3 (10.3) | 7 (33.3) |
| High BNP | 0 (0) | 7 (70.0) | 11 (55.0) | 2 (20.0) | 8 (66.7) | |
| p Value | 1.00 | 0.20 | 0.26 | 0.03 | 0.09 | |
| Severe valve disease, n (%) | Normal BNP | – | 3 (13) | 1 (10) | 15 (52) | 15 (71) |
| High BNP | – | 5 (50) | 4 (20) | 9 (90) | 6 (50) | |
| p Value | – | 0.03 | 0.64 | 0.06 | 0.27 | |
| LV end-diastolic volume index (mL/m2) | Normal BNP | 52±12 | 50±17 | 45±7 | 88±27 | 78±14 |
| High BNP | 53±16 | 48±17 | 42±13 | 100±31 | 75±14 | |
| p Value | 0.96 | 0.73 | 0.50 | 0.20 | 0.59 | |
| LV end-systolic volume index (mL/m2) | Normal BNP | 19±7 | 19±9 | 16±5 | 32±13 | 28±6 |
| High BNP | 19±60.89 | 24±190.95 | 16±60.91 | 39±170.25 | 26±70.81 | |
| p Value | ||||||
| LV ejection fraction (%) | Normal BNP | 64±8 | 61±7 | 63±8 | 64±6 | 64±7 |
| High BNP | 65±9 | 63±6 | 62±7 | 63±6 | 66±7 | |
| p Value | 0.90 | 0.47 | 0.57 | 0.54 | 0.57 | |
| LA area index (cm2/m2) | Normal BNP | 10±2 | 11±2 | 15±2 | 10±2 | 17±4 |
| High BNP | 11±3 | 13±3 | 21±6 | 12±2 | 18±5 | |
| p Value | 0.69 | 0.008 | 0.0005 | 0.07 | 0.47 | |
| Pulmonary artery pressure (mm Hg) | Normal BNP | 24±4 | 31±6 | 34±16 | 27±6 | 32±7 |
| High BNP | 25±6 | 35±7 | 36±9 | 32±6 | 47±16 | |
| p Value | 0.77 | 0.16 | 0.14 | 0.06 | 0.008 | |
| Valve area index/EROA index (cm2/m2) | Normal BNP | – | 0.51±0.13 | 0.75±0.15 | 0.10±0.07 | 0.34±0.16 |
| High BNP | – | 0.41±0.09 | 0.62±0.14 | 0.16±0.08 | 0.32±0.16 | |
| p Value | 0.04 | 0.03 | 0.02 | 0.72 | ||
| Exercise capacity (METS), | Normal BNP | 12±3 | 10±3 | 8±3 | 11±4 | 10±2 |
| High BNP | 14±3 | 7±2 | 5±2 | 11±3 | 7±2 | |
| pValue | 0.22 | 0.003 | 0.02 | 0.65 | 0.001 |
All data is mean±SD unless otherwise stated. p Values relate to comparison of normal versus raised BNP groups.
BNP, brain natriuretic peptide; EROA, effective regurgitant orifice area; LA, left atrium; LV, left ventricle; METS, metabolic equivalents; NYHA, New York Heart Association.