Table 4.

Correlation analysis summary

Variables	Correlation
Changes in DAS28 up to week 12 vs week 24	Moderate-to-high positive correlations (table 2)
Changes in GLOESS (22 paired joints, reduced 9 paired joint set) from baseline up to week 12 vs baseline to week 24	Moderate-to-high positive correlations (table 3)
Changes in GLOESS (MCPs 2–5, 22 paired joints, reduced 9 paired joint set) from baseline up to week 12 and lower levels of synovitis* at week 24	Low-to-moderate negative correlations (see online supplementary table S2)
Changes in GLOESS at week 1 and changes in GLOESS during the entire treatment period (baseline to week 24)	Low correlation
Changes in DAS28 and changes in GLOESS (MCPs 2–5, 22 paired joints, reduced 9 paired joint set, 28 joints†) or component scores (SH, PD, JE) from baseline	No correlation at any time points
GLOESS (MCPs 2–5) or component scores (SH, PD, JE) vs SJC	Very low correlation at all time points
GLOESS (MCPs 2–5) or component scores (SH, PD, JE) vs TJC	Very low correlation at all time points
GLOESS (MCPs 2–5) or component scores (SH, PD, JE) vs SJC + TJC combined	Very low correlation at all time points
Changes in GLOESS (MCPs 2–5, 22 paired joints, reduced 9 paired joint set) or components (SH, PD, JE) up to week 4 vs change in the sum of swollen joints (MCPs 2–5, 22 paired joints, reduced 9 paired joint set) at weeks 12 and 24	No correlation

*Defined by a GLOESS at week 24 that was less than the median GLOESS at that time point.

†The 28 joints assessed for tenderness and swelling as part of the DAS28.

DAS28, Disease Activity Score 28; GLOESS, Global OMERACT-EULAR Synovitis Score; JE, joint effusion; MCPs, metacarpophalangeal joints; PD, power Doppler-assessed synovial vascularisation; SH, hypoechoic synovial hyperplasia; SJC, swollen joint count; TJC, tender joint count.