Figure 1.
The schematic graph of cryo-thermal therapy using murine breast tumor model and the therapeutic efficacy. (A) Balb/c female mice were s.c. injected with 5×105 4T1 cells and received treatment after 3 weeks. (B) Kaplan-Meier survival curve. Survival curves were compared using log-rank tests. ***p<0.0001. (C) Tumor growth curves. (D) Cryo-thermal therapy could effectively inhibit or reduce tumor metastasis to lung. Data are shown as mean ± SD. **p < 0.01, ***p < 0.001 by two-way ANOVA with the Bonferroni correction. n=14 per group.