Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2016 Jan 12;2:15041. doi: 10.1038/celldisc.2015.41

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2016 SIBS, CAS

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

PMC Copyright notice

Skeletal muscle gene expression profiles are altered with XRCC1 deletion. (a) Muscle-specific gene markers myoD, myogenin are unaffected by XRCC1 expression, whereas Mef2c and MCK inductions are significantly reduced in XRCC1-deleted cells (n=3, two-tailed Student's t-test analysis with ***P-value<0.01, **P-value<0.025, *P-value<0.05). (b) p21 gene expression profile during early differentiation. Xrcc1^flox/flox primary myoblasts infected with Ctl-ad (blue) or Cre-ad (red) and induced to differentiate up to 72 h displayed reduced p21 induction (c) ChIP-end point PCR of the p21 promoter region shows enhancement of XRCC1 binding during early differentiation of C2C12 cells compared with growth conditions (n=3). Caspase 3 inhibition (DEVD) leads to loss of XRCC1-p21 promoter binding. EF1alpha is used as a non-target genomic control for the ChIP experiment.